2.3 糖肽
糖基化是一种有效的多肽修饰方法,可以改善肽的药代动力学特征和膜渗透性。糖肽化学合成的一个关键步骤是将糖基与多肽共价偶联。主要有两种方法:一个是对适当保护的全长多肽进行直接糖基化;另一个是使用预先形成的糖基化氨基酸构建块逐步合成多肽主链。目前,最常用的糖肽类合成方法是采用预先形成的糖基化氨基酸模块进行逐步多肽固相合成(Solid Phase Peptide Synthesis,SPPS)。
不同糖基化修饰示意图
科缔思生物拥有各类O-糖基化和N-糖基化合成糖氨基酸合成砌块,能够为客户提供多样化糖肽定制服务。此外,科缔思生物前期所开发的独有糖基化修饰还能够实现精氨酸糖基化修饰多肽的高效获取。
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